Naoko Niho Selected Research

Intestinal Polyps

4/2008	Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice.
10/2007	Improvement of hyperlipidemia by indomethacin in Min mice.
10/2006	Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac.
4/2006	Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice.
5/2005	Suppression of azoxymethane-induced colon cancer development in rats by a prostaglandin E receptor EP1-selective antagonist.
2/2005	Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice.
11/2003	Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPAR gamma ligand.
9/2003	Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands.

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Naoko Niho Research Topics

Disease

8	Intestinal Polyps 04/2008 - 09/2003
8	Hyperlipidemias (Hyperlipidemia) 10/2007 - 09/2003
8	Carcinogenesis 08/2007 - 01/2003
8	Colonic Neoplasms (Colon Cancer) 10/2006 - 11/2003
7	Neoplasms (Cancer) 10/2007 - 01/2003
3	Adenocarcinoma 08/2007 - 05/2005
3	Polyps 03/2006 - 09/2003
2	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 04/2008 - 09/2003
2	Carcinoma (Carcinomatosis) 10/2006 - 05/2005
2	Aberrant Crypt Foci 10/2006 - 04/2006
1	Hypertriglyceridemia 04/2008
1	Type 2 Diabetes Mellitus (MODY) 10/2007
1	Diabetes Mellitus 10/2007
1	Pancreatic Neoplasms (Pancreatic Cancer) 08/2007
1	Body Weight (Weight, Body) 10/2006
1	Colorectal Neoplasms (Colorectal Cancer) 03/2006
1	Inflammation (Inflammations) 01/2006
1	Intestinal Polyposis (Polyposis, Intestinal) 09/2003
1	Breast Neoplasms (Breast Cancer) 01/2003
1	Adenomyosis 06/2002

Drug/Important Bio-Agent (IBA)

5	LipidsIBA 10/2007 - 02/2005
5	PPAR gammaIBA 08/2007 - 09/2003
4	Triglycerides (Triacylglycerol)IBA 04/2008 - 09/2003
4	PPAR alphaIBA 10/2007 - 09/2003
4	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2007 - 09/2003
4	Messenger RNA (mRNA)IBA 10/2007 - 02/2005
4	Pioglitazone (Actos)FDA Link 08/2007 - 09/2003
3	LigandsIBA 08/2007 - 09/2003
3	AzoxymethaneIBA 10/2006 - 05/2005
2	nitrosobis(2-oxopropyl)amine (NBOP)IBA 10/2007 - 08/2007
2	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 04/2006 - 02/2005
2	CholesterolIBA 04/2006 - 09/2003
2	4- diethoxyphosphorylmethyl- N- (4- bromo- 2- cyanophenyl)benzamideIBA 04/2006 - 02/2005
2	BezafibrateIBA 04/2006 - 09/2003
2	Prostaglandins EIBA 12/2005 - 05/2005
2	ProstaglandinsIBA 12/2005 - 05/2005
2	Prostaglandin E Receptors (Prostaglandin E Receptor)IBA 12/2005 - 05/2005
1	Plasminogen Activators (Plasminogen Activator)IBA 04/2008
1	AdipokinesIBA 04/2008
1	Plasminogen Activator Inhibitor 1IBA 04/2008
1	Indomethacin (Indometacin)FDA LinkGeneric 10/2007
1	Cyclooxygenase InhibitorsIBA 10/2007
1	mofezolacIBA 10/2006
1	Cyclooxygenase 1IBA 10/2006
1	3,4,11- trihydroxy- 2- (hydroxymethyl)- 8- (4- hydroxyphenyl)- 3,4,4a,11b- tetrahydro- 2H,10H- pyrano(2',3'- 4,5)furo(3,2- g)chromen- 10- oneIBA 04/2006
1	flavoneIBA 04/2006
1	TeaIBA 04/2006
1	3-nitrotyrosineIBA 01/2006
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2006
1	beta CateninIBA 01/2006
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2006
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2006
1	Dextrans (Dextran)FDA Link 01/2006
1	ONO 8711IBA 05/2005
1	Bromodeoxyuridine (BrdU)IBA 05/2005
1	Troglitazone (Rezulin)FDA Link 11/2003
1	PPAR-gamma AgonistsIBA 11/2003
1	Hormones (Hormone)IBA 01/2003
1	GenisteinIBA 01/2003
1	9,10-Dimethyl-1,2-benzanthraceneIBA 01/2003
1	CP8863IBA 06/2002
1	Progesterone Receptors (Progesterone Receptor)IBA 06/2002
1	CP8816IBA 06/2002

Therapy/Procedure

1	Ovariectomy (Oophorectomy) 01/2003